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![These highlights do not include all the information needed to use TREXALL® safely and effectively. See full prescribing information for TREXALL. TREXALL® (methotrexate tablets), for oral use Initial U.S. Approval: 1953 These highlights do not include all the information needed to use TREXALL® safely and effectively. See full prescribing information for TREXALL. TREXALL® (methotrexate tablets), for oral use Initial U.S. Approval: 1953](https://dailymed.nlm.nih.gov/dailymed/image.cfm?name=image-4.jpg&id=659159)